產品及服務

MP Biomedicals (ICN)

DSS

Dextran Sulfate Sodium Salt

產品說明
做動物實驗時總是找不到適合的 Compound 誘發嗎？還在尋找誘發 Colitis 的藥物嗎？MP 提供你 Glod Grade 的 Dextran Sulfate Sodium Salt (DSS)，目前已超過300篇的Ref. 指定使用，好評不斷！
protocol (94 KB)
功能說明
 Dextran Sulfate Sodium Salt (DSS) 除了可以增加核酸雜交比例之外，也可刺激B細胞分化或是抑制血液凝固，此外因為DSS會誘發小鼠腸道潰爛或結腸炎(Colitis)，因此做消化道系統或是一些藥物開發都需要這個藥物幫忙，先將此藥灌食實驗動物後，等已對結腸造成傷害，在做新藥給予的動作

原廠連結
規格說明
貨號       包裝
0216011001    1g 
0216011010   10g
0216011025   25g
0216011050   50g
0216011080  100g
0216011090  500g
其它說明1
  • Highest sulfur content: 19%
  • Highest chirality: +104° of specific rotation
  • Lowest pH: 6.2 at 1% solution

Bamba et al. (2012) performed a comparative analysis of 3 different DSS preparations to examine the chemical and cytotoxic properties as well as severity of colitis. 

 
其它說明2
 

  • Crncec, I., et al. Induction of colorectal cancer in mice and histomorphometric evaluation of tumors. Methods Mol. Biol. 1267, 145–64 (2015).

  • Grill, J. et al. Intestinal E-cadherin Deficiency Aggravates Dextran Sodium Sulfate-Induced Colitis. Dig. Dis. Sci. 60, 895–902 (2015).

  • Huang, Z. et al. An orally administrated nucleotide-delivery vehicle targeting colonic macrophages for the treatment of inflammatory bowel disease. Biomaterials 48, 26–36 (2015).

  • Utrilla, M. P. et al. Pea (Pisum sativum L.) seed albumin extracts show anti-inflammatory effect in the DSS model of mouse colitis. Mol. Nutr. Food Res. 59, 807–19 (2015).

  • Zhang, Y., Brenner, M., Yang and TNBS-induced colitis in mice. Lab. Invest. 95, 480–90 (2015).

  • Sales-Campos, H. et al. Aedes aegypti salivary gland extract ameliorates experimental inflammatory bowel disease. Int. Immunopharmacol. 26, 13–22 (2015).

  • Belkind-Gerson, J. et al. Colitis induces enteric neurogenesis through a 5-HT4-dependent mechanism. Inflamm. Bowel Dis. 21, 870–8 (2015).

  • Hasby, E. et al. T regulatory cells and immunomodulation after Schistosoma mansoni egg antigen immunization in experimental model of inflammatory bowel disease. Cell. Immunol. 295, 67–76 (2015).

  • He, J. et al. NPC1L1 knockout protects against colitis-associated tumorigenesis in mice. BMC Cancer 15, 189 (2015).

  • Nakamura, S. et al. Erythropoietin attenuates intestinal inflammation and promotes tissue regeneration. Scand. J. Gastroenterol. 50, 1094–102 (2015).

  • Garrido-Mesa, J. et al. A new therapeutic association to manage relapsing experimental colitis: Doxycycline plus Saccharomyces boulardii. Pharmacol. Res. 97, 48–63 (2015).

  • Li, J. et al. Ternary polyplex micelles with PEG shells and intermediate barrier to complexed DNA cores for efficient systemic gene delivery. J. Control. Release 209, 77–87 (2015).

  • Nagy-Szakal, D. et al. Loss of n-6 fatty acid induced pediatric obesity protects against acute murine colitis. FASEB J. 29, 3151–9 (2015).

  • Wen, J. et al. The role of Th17/Treg balance and Th22 cell in the pathogenesis of DSS-induced colitis in mice. Eur. J. Inflamm. 13, 101–108 (2015).

  • Rauch, I. et al. Noncanonical Effects of IRF9 in Intestinal Inflammation: More than Type I and Type III Interferons. Mol. Cell. Biol. 35, 2332–43 (2015).

  • Saijo, H. et al. Microangiopathy triggers, and inducible nitric oxide synthase exacerbates dextran sulfate sodium-induced colitis. Lab. Invest. 95, 728–48 (2015).

  • Jain, U et al Regulation of Complement Activation Affects Colitis in Interleukin 10 Gene-Deficient Mice. Inflamm. Bowel Dis. 21, 1519–28 (2015).

  • Li, M. et al. Endomicroscopy Will Track Injected Mesenchymal Stem Cells in Rat Colitis Models. Inflamm. Bowel Dis. 21, 2068–77 (2015).

  • Zhang, J. et al. Ginsenosides Regulate PXR/NF-?B Signaling and Attenuate Dextran Sulfate Sodium-Induced Colitis. Drug Metab. Dispos. 43, 1181–9 (2015).

  • Gurav, A. et al. Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions. Biochem. J. 469, 267–78 (2015).

  • Dai, X. et al. MicroRNA-193a-3p Reduces Intestinal Inflammation in Response to Microbiota via Down-regulation of Colonic PepT1. J. Biol. Chem. 290, 16099–115 (2015).

  • Yokoyama, S., et al. Impairment of skin barrier function via cholinergic signal transduction in a dextran sulphate sodium-induced colitis mouse model. Exp. Dermatol. 24, 779–84 (2015).

  • Reichmann, F. et al. Dextran sulfate sodium-induced colitis alters stress-associated behaviour and neuropeptide gene expression in the amygdala-hippocampus network of mice. Sci. Rep. 5, 9970 (2015).

  • Erickson, N. A. et al. The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice. PLoS One 10, e0131991 (2015).

  • Wen, Y.-A. et al. Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis. Biochim. Biophys. Acta 1852, 2013–23 (2015).

  • Cho, J. Y. et al. ß-Caryophyllene attenuates dextran sulfate sodium-induced colitis in mice via modulation of gene expression associated mainly with colon inflammation. Toxicol. Reports 2, 1039–1045 (2015).

  • Wu, J. et al. Glucagon-like peptide-2-loaded microspheres as treatment for ulcerative colitis in the murine model. J. Microencapsul. 32, 598–607 (2015).

  • Naeem, M. et al. Colon-targeted delivery of budesonide using dual pH- and time-dependent polymeric nanoparticles for colitis therapy. Drug Des. Devel. Ther. 9, 3789–99 (2015).

  • Vitali, R. et al. Dipotassium glycyrrhizate via HMGB1 or AMPK signaling suppresses oxidative stress during intestinal inflammation. Biochem. Pharmacol. 97, 292–9 (2015).

  • Pandurangan, A. et al.. Gallic acid attenuates dextran sulfate sodium-induced experimental colitis in BALB/c mice. Drug Des. Devel. Ther. 9, 3923–34 (2015).

 
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